Natural products branch developmental therapeutics program

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Planta Med. J Plant Interact. Fung Biol. Gunatilaka AAL. Carter GT. Support Center Support Center. External link. Please review our privacy policy. With all source categories Figure 1. All subdivisions Figure 3. By year Figure 5. By year Figure 6. Generic and trade names, year, reference and source Table 2. Generic and trade names, year, reference and source Table 3.

Leslie Gunatilaka, Eli Chapman. Biochemistry , 58 30 , Journal of Natural Products , 82 5 , Principe, William S. Journal of Natural Products , 81 10 , Egbewande, Martin C. Sadowski, Claire Levrier, Kaylyn D. Tousignant, Jonathan M. White, Mark J. Coster, Colleen C. Nelson, Rohan A. Journal of Natural Products , 81 4 , Craig, II, Russell C.

Smith, Jennifer L. Roizen, Amanda C. Jones, Scott C. Virgil, Brian M. The Journal of Organic Chemistry , 83 7 , Newman and Gordon M. Natural Products as Sources of New Drugs from to Journal of Natural Products , 79 3 , Journal of Natural Products , 78 6 , Tigliane Diterpenoids from the Euphorbiaceae and Thymelaeaceae Families.

Chemical Reviews , 9 , Journal of Chemical Information and Modeling , 54 9 , Journal of Medicinal Chemistry , 57 13 , Chemical Reviews , 12 , ACS Combinatorial Science , 16 5 , Lambu , Suresh Kumar , Syed K. Yousuf , Deepak K. Journal of Medicinal Chemistry , 56 15 , Chemical Reviews , 11 , Biomimetic Semisynthesis of Arglabin from Parthenolide. The Journal of Organic Chemistry , 77 16 , Cantrell , Franck E.

Dayan , and Stephen O. Journal of Natural Products , 75 6 , Pauli , Shao-Nong Chen , J. Brent Friesen , James B. McAlpine , and Birgit U.

Journal of the American Chemical Society , 21 , Organic Letters , 14 7 , Journal of Natural Products , 75 1 , Journal of Agricultural and Food Chemistry , 59 18 , Roberts , Mark A. Schallenberger , Jian Liu , Peter A. Smith , and Floyd E. Journal of Medicinal Chemistry , 54 14 , Journal of Medicinal Chemistry , 52 7 , Plant Orthoesters.

Chemical Reviews , 3 , Journal of Natural Products , 71 11 , Bacterial Hosts for Natural Product Production. Molecular Pharmaceutics , 5 2 , Quinn , Anthony R. Carroll , Ngoc B. Pham , Paul Baron , Meredith E. Palframan , Lekha Suraweera , Gregory K. Pierens and Sorel Muresan. Developing a Drug-like Natural Product Library.

Journal of Natural Products , 71 3 , Pauli,, Birgit U. Jaki, and, David C. Journal of Natural Products , 70 4 , Richard Hutchinson.

Genetic Approaches to Polyketide Antibiotics. Chemical Reviews , 2 , Meutermans,, Gregory T. Bourne,, Simon W. Golding,, Douglas A. Horton,, Marc R. Organic Letters , 5 15 , Journal of Chemical Information and Computer Sciences , 43 2 , Reeves,, Raghavan Balachandran,, Kenneth A. Thus, in the area of cancer, over the time frame from around the s to date, of the small molecules, , or In other areas, the influence of natural product structures is quite marked, with, as expected from prior information, the anti-infective area being dependent on natural products and their structures.

Although combinatorial chemistry techniques have succeeded as methods of optimizing structures and have been used very successfully in the optimization of many recently approved agents, we are able to identify only one de novo combinatorial compound approved as a drug in this year time frame.